Mapping prognostic factors for globe survival in panophthalmitis using logistic regression and Cox proportional hazard models: A retrospective study

Purpose: The aim of this study was to report the outcomes of panophthalmitis and to identify factors significantly affecting globe survival in the disease. Methods: This was a retrospective study on patients with panophthalmitis in a tertiary hospital between January 1, 2017, and December 31, 2019. The demographics, treatment details, culture results, and final outcomes were recorded. Logistic regression and Cox proportional hazards (CPH) were calculated to identify variables associated with globe loss. A P < 0.05 was considered significant. Results: Eighty?five eyes of 85 patients (31 culture positive) were eligible for review. The mean age of the participants was 55.21 ± 20.17 years with a male?to?female ratio of 2.04:1. Corneal ulcer (38.82%; n = 33) and open globe injuries (OGIs) (38.82%; n = 33) were the most common etiologies. Pseudomonas aeruginosa (n = 10; 11.76%) was the most common isolate. The mean duration of hospital stay was 7.58 ± 2.32 days. Overall, 44 (51.76%) globes could be salvaged. The need for evisceration (P = 0.901) and hospital stays (P = 0.095) were similar for culture?positive and ?negative cohorts. The unadjusted logistic regression and CPH models showed that culture sterility did not affect globe survival [OR = 1.210 (0.501– 2.950), P = 0.668; HR = 1.176 (0.617–2.243), P = 0.623]. The adjusted logistic regression and the CPH models showed that corneal ulcers [OR = 10.900 (2.460–48.200), P = 0.002; HR = 5.393 (1.603–18.140), P = 0.006] and OGI [OR = 7.360 (1.650–32.700), P = 0.009; HR = 4.548 (1.321–15.660), P = 0.016] were significantly associated with globe loss. Conclusion: Corneal ulcer or OGI as the primary etiology is detrimental to globe survival in panophthalmitis.

Every eye needs a best chance to see: Just give it

Background: Anterior staphyloma is defined as a localized defect in the anterior eye wall with protrusion of the uveal tissue due to alterations in scleral thickness and structure. The causes could be congenital, trauma, or following infection. Surgical options include staphylectomy with graft (corneal/ corneoscleral), biosynthetic graft, enucleation or evisceration in a painful blind eye). Purpose: To demonstrate staphylectomy with careful preservation of ocular structures followed by optical keratoplasty in a single setting. Synopsis: A 39?year?old Asian Indian lady presented with complaints of blurring of vision and whitish opacity in both eyes since childhood, associated with progressive enlargement and protrusion of the black part of the left eye with severe pain at the time of presentation. Her clinical examination revealed leucomatous corneal opacity in both the eyes and anterior staphyloma and keratinization in the left eye. Visual acuity was counting fingers close to face in the right eye and hand movements close to face in the left eye with projection of rays being accurate in both eyes. Ultrasound B scan showed posterior staphyloma in the right eye with sub?Tenon’s fluid and increased retinochoroidal thickness. The left eye posterior segment with B scan was normal. The available surgical options were evisceration with secondary orbital implant and ocular prosthesis or staphylectomy with corneal transplantation. To provide the best option for the patient in her eye with better visual potential, staphylectomy with corneal transplantation was done. Highlights: Painful blind eye is usually dealt with evisceration. This video demonstrates the technique of staphylectomy with corneal graft and restoration of structural integrity. Evisceration is a destructive procedure that involves removal of the intraocular contents. The patient will have to deal with the hassles of prosthesis maintenance and stigma of the artificial eye

Clinical and histopathological study of a hollow and posteriorly multiperforated polymethylmethacrylate implant in eviscerated rabbit eyes / Análise clínica e histopatológica de um implante de polimetilmetacrilato oco e multiperfurado em sua porção posterior em olhos eviscerados de coelhos

ABSTRACT Purpose: The study aimed to evaluate the clinical and tissue response to a hollow polymethylmethacrylate orbital implant with a multiperforated posterior surface in an animal model after evisceration. Methods: Sixteen New Zealand rabbits had their right eye eviscerated. All animals received a hollow polymethylmethacrylate implant 12 mm in diameter that is multiperforated in its posterior hemisphere. The animals were divided into four groups, and each one had the eye exenterated at 7, 30, 90, and 180 days post-evisceration. Clinical signs were assessed daily for 14 days post-evisceration and then every 7 days until 180 days. Inflammatory pattern, collagen structure, and degree of neovascularization generated with implant placement were analyzed with hematoxylin-eosin, picrosirius red, and immunohistochemistry staining. Results: There were no signs of infection, conjunctival or scleral thinning, or implant exposure or extrusion in any animal during the study. On day 7, the new tissue migrated into the implant and formed a fibrovascular network through the posterior channels. Inflammatory response reduced over time, and no multinuclea­ted giant cells were found at any time. Conclusion: Hollow polymethylmethacrylate orbital implants with a multiperforated posterior surface enable rapid integration with orbital tissues by fibrovascular ingrowth. We believe that this orbital implant model can be used in research on humans.

RESUMO Objetivo: Avaliar a resposta tecidual e clínica a um implante orbitário de polimetilmetacrilato, oco e multiperfu­rado em sua porção posterior em modelo animal após evisceração. Métodos: Dezesseis coelhos da raça Nova Zelândia foram submetidos à evisceração do globo ocular direito. Todos receberam implante oco de polimetilmetacrilato de 12 mm de diâmetro, multiperfurado em sua semiesfera posterior. O estudo foi dividido em avaliação clínica e histopatológica. A avaliação clínica foi diária até 14 dias pós-evisceração e, a cada sete dias, até completar 180 dias. Os animais foram divididos em grupos de quatro animais e cada um foi submetido à exenteração com 07, 30, 90 e 180 dias e depois à eutanásia. A análise histopatológica teve por fim caracterizar o padrão inflamatório, a estrutura do colágeno e o grau de neovascularização. Para isso, além da tradicional coloração pela hematoxilina-eosina, utilizou-se o corante Picrosirius Red (PSR) e imuno-histoquímica com o marcador CD 34. Resultados: Não houve sinais de infecção, afinamento conjuntival ou escleral, exposição ou extrusão do implante em nenhum animal durante o estudo. Já no sétimo dia, o tecido neoformado migrou para dentro do implante formando uma rede fibrovascular através dos canais posteriores. A resposta inflamatória diminuiu ao longo do tempo avaliado e não foram encontradas células gigantes multinucleadas. Conclusão: O implante analisado permite a sua integração aos tecidos orbitários pelo crescimento fibrovascular em seu interior. Os autores acreditam que este modelo de implante orbital pode fazer parte de testes com humanos.

Evisceration and enucleation cases in the ophthalmologic emergency department of a tertiary Brazilian hospital / Casos de evisceração e enucleação em departamento de urgência oftalmológica de um hospital terciário Brasileiro

ABSTRACT Purpose: To analyze the epidemiological profiles of evisceration and enucleation cases in the ophthalmologic emergency department of a Brazilian tertiary hospital. Methods: Patients treated in the ophthalmologic emergency department of Hospital São Paulo (Universidade Federal de São Paulo) during the period 2013 to 2018 were retrospectively evaluated. Urgent cases of evisceration or enucleation surgery were included, and elective cases were excluded. The following information was extracted from the patients' medical records: demographic data, immediate and associated reasons for the surgical procedure, informed visual acuity, symptom duration until ophthalmologic care, complications, distance from the residence to the tertiary hospital, and time of hospitalization. Results: In total, 61 enucleations and 121 eviscerations were included in this study. The patients had a mean age of 63.27 ± 18.68 years. Of the patients, 99 were male (54.40%), and 83 were female (45.60%). The indications for evisceration or enucleation were corneal perforation with (44.50%) and without (23.63%) signs of infection, endophthalmitis (15.38%), ocular trauma (14.29%), neoplasia (0.55%), burn accident (1.10%), and phthisis bulbi (0.55%). The self-reported visual acuity was no light perception (87.36%) or light perception (1.10%). However, 3.30% of the patients did not cooperate with the examination, and no information on visual acuity was available for the remaining 8.24%. The mean symptom duration before ophthalmologic care was sought was 18.32 days. Two patients had sympathetic ophthalmia after evisceration. Conclusions: More eviscerations than enucleations were performed throughout the study period. The most common demographic characteristics were age >60 years and male sex. The main indications for urgent evisceration and enucleation procedures were corneal perforation with and without infection, endophthalmitis, and ocular trauma. The findings from this study could guide clinicians in performing preventive measures to avoid destructive eye procedures.

RESUMO Objetivo: Analisar o perfil epidemiológico dos casos de evisceração e enucleação no pronto-socorro oftalmológico de um hospital terciário brasileiro. Métodos: Análise retrospectiva dos casos tratados no pronto-socorro oftalmológico do Hospital São Paulo (Universidade Federal de São Paulo) entre os anos de 2013 a 2018. Os casos urgentes de evisceração e enucleação foram incluídos e os casos eletivos foram excluídos. A análise dos prontuários médicos foi baseada em: dados demográficos, causas imediatas e associadas ao procedimento, acuidade visual informada, duração dos sintomas antes do atendimento oftalmológico, complicações, distância da residência até o hospital e tempo de hospitalização. Resultados: 61 enucleações e 121 eviscerações foram incluídas no estudo. Os pacientes tinham uma média de idade de 63,27 ± 18,68 anos; 99 eram do sexo masculino (54,50%) e 83 do sexo feminino (45,60%). As indicações de evisceração e enucleação foram: perfuração corneana com (44,50%) e sem (23,63%) sinais infecciosos, endoftalmite (15,38%), trauma ocular (14,29%), neoplasia (0,55%), queimadura (1,10%) e phthisis bulbi (0,55%). A acuidade visual informada foi de ausência de percepção luminosa (87,36%), percepção luminosa (1.10%), ausência de colaboração (3,30%) e sem dados informados (8,24%). A média de tempo até a busca pelo serviço oftalmológico foi de 18,32 dias. Houve 2 casos de oftalmia simpática após evisceração. Conclusões: Eviscerações foram predominantemente realizadas em comparação a enucleações em todo o período de estudo. As características demográficas mais comuns foram idade >60 anos e sexo masculino. As principais indicações para procedimentos urgentes de evisceração e enucleação foram perfuração corneana com e sem infecção, endoftalmite e trauma ocular. Este estudo poderia guiar medidas preventivas para evitar procedimentos oculares destrutivos.

Evisceración intestinal transvaginal incarcerada con perforación intestinal después de una colporrafia con malla. Reporte de un caso / Incarcerated transvaginal bowel evisceration with intestinal perforation after a mesh colporraphy. A case report

Introducción. La evisceración intestinal transvaginal es consecuencia, en la gran mayoría de casos, de dehiscencia del muñón vaginal posterior a histerectomía en pacientes postmenopáusicas. A través de la dehiscencia vaginal se produce la salida del contenido abdominopélvico, que puede presentarse como una evisceración simple, incarceración, obstrucción, estrangulamiento y perforación de un asa intestinal. Caso clínico. Mujer de 78 años, con antecedente inmediato de colpocleisis y colporrafia con malla de polipropileno por prolapso vaginal, que presentó dehiscencia del muñón vaginal debido a rechazo de la malla, que condicionó la solución de continuidad de la pared vaginal, con prolapso, incarceración, obstrucción y perforación de íleon. Con el diagnóstico de evisceración intestinal transvaginal incarcerada con perforación intestinal se llevó a tratamiento quirúrgico, con abordaje inicial por vía vaginal para liberar el asa intestinal, luego por laparotomía se realizó resección y anastomosis de íleon, sacrocolpopexia con malla y plastia de Douglas. Presentó buena evolución postoperatoria.Conclusión. La evisceración intestinal transvaginal con perforación intestinal es una entidad de muy rara presentación. El órgano más frecuentemente comprometido es el intestino delgado, especialmente el íleon. Puede complicarse con incarceración, obstrucción intestinal, isquemia y perforación. El manejo quirúrgico involucra resección intestinal, cuando hay signos de necrosis, con reparación y fijación del muñón vaginal.

Introduction. Transvaginal intestinal evisceration is a consequence, in the vast majority of cases, of dehiscence of the vaginal stump after hysterectomy in postmenopausal patients. Through vaginal dehiscence, the exit of the abdominopelvic content occurs, which can present as a simple evisceration, incarceration, obstruction, strangulation and perforation of an intestinal loop. Clinical case. A 78-year-old woman with an immediate history of colpocleisis and polypropylene mesh colporrhaphy due to vaginal prolapse, presents dehiscence of the vaginal stump caused by rejection of the mesh that conditioned the solution of continuity of the vaginal wall, prolapse, incarceration, obstruction and perforation of the ileum. Surgical treatment was performed with the diagnosis of incarcerated transvaginal intestinal evisceration with intestinal perforation. The initial approach was to free the intestinal loop vaginally, followed by laparotomy, ileal resection and anastomosis, mesh sacrocolpopexy, and Douglas plasty were performed. He presented good postoperative evolution.Conclussion. Transvaginal intestinal evisceration with intestinal perforation is a very rare entity. The most common organ involved is the small intestine, especially the ileum. It can be complicated by incarceration, intestinal obstruction, ischemia, and perforation. Surgical management involves intestinal resection, when there are signs of necrosis, with repair and fixation of the vaginal stump.

Every eye needs a best chance to see: Just give it

Background: Anterior staphyloma is defined as a localized defect in the anterior eye wall with protrusion of the uveal tissue due to alterations in scleral thickness and structure. The causes could be congenital, trauma, or following infection. Surgical options include staphylectomy with graft (corneal/ corneoscleral), biosynthetic graft, enucleation or evisceration in a painful blind eye). Purpose: To demonstrate staphylectomy with careful preservation of ocular structures followed by optical keratoplasty in a single setting. Synopsis: A 39?year?old Asian Indian lady presented with complaints of blurring of vision and whitish opacity in both eyes since childhood, associated with progressive enlargement and protrusion of the black part of the left eye with severe pain at the time of presentation. Her clinical examination revealed leucomatous corneal opacity in both the eyes and anterior staphyloma and keratinization in the left eye. Visual acuity was counting fingers close to face in the right eye and hand movements close to face in the left eye with projection of rays being accurate in both eyes. Ultrasound B scan showed posterior staphyloma in the right eye with sub?Tenon’s fluid and increased retinochoroidal thickness. The left eye posterior segment with B scan was normal. The available surgical options were evisceration with secondary orbital implant and ocular prosthesis or staphylectomy with corneal transplantation. To provide the best option for the patient in her eye with better visual potential, staphylectomy with corneal transplantation was done. Highlights: Painful blind eye is usually dealt with evisceration. This video demonstrates the technique of staphylectomy with corneal graft and restoration of structural integrity. Evisceration is a destructive procedure that involves removal of the intraocular contents. The patient will have to deal with the hassles of prosthesis maintenance and stigma of the artificial eye.

Rotura vaginal y evisceración relacionadas a úlcera de contacto por útero prolapsado: reporte de caso / Vaginal rupture and evisceration related to contact ulcer due to prolapsed uterus: case report

RESUMEN La evisceración vaginal se presenta en 0,36% a 0,96% de las pacientes postoperadas de histerectomía. La causa más frecuente es la dehiscencia de la cúpula vaginal, con mayor riesgo en la histerectomía laparoscópica en relación a la de abordaje abierto. Se describe el caso de una mujer de 63 años con historia de prolapso total de útero, sin antecedente quirúrgico, que ingresó a emergencia por evisceración vaginal. La rotura ocurrió en la pared vaginal posterior, en donde se había formado una úlcera por roce. Se realizó laparotomía para reducir el intestino y reparar el desgarro de la pared vaginal. La corrección del prolapso se practicó ocho meses después con resultados satisfactorios. El tipo de cirugía reparadora depende del tipo y viabilidad de la víscera herniada y se puede realizar por vía vaginal, abdominal o combinada, mediante laparotomía o laparoscopia.

ABSTRACT Vaginal evisceration occurs in 0.36% to 0.96% of postoperative hysterectomy patients. The most frequent cause is vaginal vault dehiscence, with a higher risk in laparoscopic hysterectomy than in open approach. We describe the case of a 63-yearold woman with a history of total prolapse of the uterus, with no surgical history, who was admitted to the emergency room for vaginal evisceration. The rupture occurred in the posterior vaginal wall, where a friction ulcer had formed. Laparotomy was performed to reduce the bowel and repair the tear in the vaginal wall. Correction of the prolapse was done eight months later with satisfactory results. The type of reparative surgery depends on the type and viability of the herniated viscus and can be performed vaginally, abdominal or combined, by laparotomy or laparoscopy.

Evisceración del intestino delgado estrangulado en una anciana con douglascele / Evisceration of the impacted small bowel in an elderly with douglascele

Se presenta el caso clínico de una anciana de 86 años de edad con evisceración del intestino delgado a través del periné. Se efectuó la exploración quirúrgica urgente del abdomen y se observó la perforación del fondo del saco de Douglas y la salida de 50 cm de intestino delgado estrangulado, de manera que se realizó la resección intestinal de todo el segmento afectado y anastomosis termino-terminal. Luego se reparó el defecto del fondo del saco de Douglas con una plastia perineal, para lo cual se utilizó una malla de polipropileno. Este proceder es una buena alternativa para el tratamiento quirúrgico en quienes presentan hernias perineales, pues permite un cierre mejor, disecar el saco herniario y reducirlo adecuadamente.

The case report of a 86 years elderly is presented with evisceration of the small bowel through the perineum. The urgent surgical exploration of the abdomen was carried out and it was observed the perforation of the Douglas pouch and the 50 cm prominence of impacted small bowel, so that the bowel resection of the whole affected segment and end to end anastomosis was carried out. Then the Douglas pouch defect was repaired with a perineal plasty, for which a polypropylene mesh was used. This procedure is a good alternative for the surgical treatment in those who present perineal hernias, because it allows a better closing, to dissect the hernial sack and to reduce it appropriately.

Evisceración vaginal post histerectomía abdominal. Presentación de un caso / Vaginal eviscerationafter abdominal hysterectomy. Filing a case / Evisceração vaginal após histerectomia abdominal. Arquivar um caso

RESUMEN Introducción: la evisceración vaginal después de una cirugía pélvica es una emergencia quirúrgica extremadamente rara. La dehiscencia laparotómica consiste en la desunión y separación precoz de los bordes de una herida quirúrgica suturada, con exteriorización o sin ella del contenido de la cavidad abdominal. Presentación de caso: el caso que aquí se reporta es el de unamujer de 36 años con antecedentes de hipertensión arterial. Intervenida hacia 3 meses de histerectomía abdominal por fibromiomas, sin prolapso uterino. Acude al cuerpo de guardia del hospital por dolor abdominal, sensación de ocupación vaginal y estreñimiento. Niega distensión abdominal y síntomas respiratorios. Ya en el cuerpo de guardia refiere deseos de defecar y al pujar ocurre una protrusión de intestino delgado de más o menos 3 cm, irreductible a través de orificio vaginal. Se realizó laparatomía, revisión por vía vaginal, reducción de las asas intestino delgado y ampliación del orificio por donde se produjo la evisceración. Discusión: se localizaron los bordes del peritoneo parietal, se sutura la cúpula vaginal con puntos continuos y se colocó una malla en el fondo de la pelvis recubierta por peritoneo. Se utilizaron los datos provenientes de la historia clínica hospitalaria. Exámenes complementarios, la entrevista y el examen físico de la paciente, a pesar las probables complicaciones no hubo pérdida de tiempo y la operación fue un éxito. Conclusiones: la evolución fue satisfactoria, gracias a la labor del personal médico que estuvo a cargo del caso.

ABSTRACT Introduction: vaginal evisceration after pelvic surgery is an extremely rare surgical emergency. Laparotomic dehiscence consists of disunity and early separation of the edges of a sutured surgical wound, with or without externalization of the contents of the abdominal cavity. Case presentation: the case reported here is that of a 36-year-old woman with a history of high blood pressure. She underwent 3 months of abdominal hysterectomy for fibromyomas, without uterine prolapse. She comes to the hospital guard corps for abdominal pain, a feeling of vaginal occupation and constipation. He denies abdominal bloating and respiratory symptoms. Already in the body of guard it refers desires to defecate and when pushing a protrusion of small intestine of more or less 3 cm occurs, irreducible through the vaginal opening. Laparatomy, vaginal revision, reduction of the small intestine loops and enlargement of the hole through which evisceration occurred were performed. Discussion: the edges of the parietal peritoneum were located, the vaginal dome was sutured with continuous stitches, and a mesh was placed at the bottom of the pelvis covered by peritoneum. The data from the hospital medical history were used. Complementary examinations, the interview and the physical examination of the patient, despite the probable complications, there was no loss of time and the operation was successful. Conclusions: the evolution was satisfactory, thanks to the work of the medical personnel who were in charge of the case.

RESUMO Introdução: a evisceração vaginal após cirurgia pélvica é uma emergência cirúrgica extremamente rara. A deiscência laparotômica consiste em desunião e separação precoce das bordas de uma ferida cirúrgica suturada, com ou sem externalização do conteúdo da cavidade abdominal. Apresentação do caso: o caso relatado aqui é o de uma mulher de 36 anos com histórico de pressão alta. Ela foi submetida a 3 meses de histerectomia abdominal por fibromiomas, sem prolapso uterino. Ele veio à guarita do hospital devido a dor abdominal, sensação de ocupação vaginal e constipação. Ele nega inchaço abdominal e sintomas respiratórios. Já no corpo de guarda refere desejos de defecar e ao empurrar uma protrusão do intestino delgado de mais ou menos 3 cm, ocorre irredutível através da abertura vaginal. Foram realizadas laparometria, revisão vaginal, redução das alças do intestino delgado e aumento do orifício através do qual a evisceração ocorreu. Discussão: as margens do peritônio parietal foram localizadas, a cúpula vaginal foi suturada com pontos contínuos e uma malha foi colocada na parte inferior da pelve coberta por peritônio. Foram utilizados os dados do histórico médico do hospital. Exames complementares, entrevista e exame físico do paciente, apesar das prováveis ​​complicações, não houve perda de tempo e a operação foi bem-sucedida. Conclusões: a evolução foi satisfatória, graças ao trabalho da equipe médica responsável pelo caso.

An innovative proposal for anophthalmic cavity reconstruction surgery with bone cement: a case report / Proposta inovadora para reconstrução de cavidades anoftálmicas utilizando cimento ósseo: um relato de caso

ABSTRACT We present a patient who underwent evisceration surgery after spontaneous rupture of the ocular globe due to long-data uncontrolled glaucoma, with posterior placement of an orbital implant made of a bone cement compound based on polymethylmethacrylate as alternative materials were not available. Such a compound is characterized by excellent biocompatibility and low cost, which makes it an interesting alternative for treatment. The anophthalmic socket was successfully filled, providing proper esthetic results and favorable conditions for the posterior scleral prosthesis implantation. No complications were observed during 10 months of follow-up. We believe that, in the absence of alternative materials, low-cost materials may be used in emergency settings to repair anophthalmic cavities and provide satisfactory functional and esthetic outcomes.

RESUMO Apresentamos um paciente que foi submetido à cirurgia de evisceração após ruptura espontânea do globo ocular devido a glaucoma não controlado de longa data, com posterior colocação de implante orbital feito de cimento ósseo, composto à base de polimetilmetacrilato, diante da indisponibilidade de materiais alternativos. Tal composto se caracteriza pela excelente biocompatibilidade e baixo custo, o que o torna uma alternativa interessante para o tratamento. A cavidade anoftálmica foi preenchida com sucesso, fornecendo resultados estéticos adequados e condições favoráveis para o implante posterior de prótese escleral. Nenhuma complicação foi observada durante os 10 meses de seguimento. Acredi­tamos que, na ausência de materiais alternativos, materiais de baixo custo podem ser usados em situações emergenciais para preencher cavidades anoftálmicas e prover resultados funcionais e estéticos satisfatórios.

Evisceración intestinal transvaginal espontánea idiopática. Reporte de caso / Idiopathic spontaneous transvaginal intestinal evisceration. Case report

Resumen ANTECEDENTES: La evisceración por vía vaginal es una urgencia quirúrgica poco frecuente, con menos de 100 reportes en la bibliografía. Se asocia con múltiples factores, el más importante es la cirugía ginecológica por vía vaginal. La presentación clínica es variable y el tratamiento consiste en cirugía de urgencia para disminuir la morbilidad y mortalidad asociada con las complicaciones. CASO CLÍNICO: Paciente de 63 años, sin antecedentes quirúrgicos o procedimientos por vía vaginal, referida del segundo nivel al Hospital Regional de Alta Especialidad de Oaxaca, con diagnóstico de evisceración por vía vaginal, posterior a una maniobra de Valsalva cuando evacuaba, con posterior sensación de cuerpo extraño en el canal vaginal. Fue valorada en el servicio de Urgencias de un hospital de tercer nivel en donde se la encontró hemodinámicamente estable, con signos vitales en parámetros normales, taquicárdica, con 103 latidos por minuto. De inmediato fue intervenida y en el transoperatorio se evidenció la ruptura de la cúpula vaginal, con evisceración y necrosis de 100 cm de íleon terminal. Se le practicaron: resección, anastomosis y cierre primario del defecto vaginal. Se le tomó biopsia del cuello uterino; la colposcopia se reportó con malignidad negativa. El posoperatorio evolucionó sin contratiempos. CONCLUSIÓN: Hasta ahora, se encuentran menos de 100 reportes de esta complicación, que requiere de sospecha y tratamiento oportuno para disminuir la morbilidad y mortalidad asociada. Lo relevante de este caso es la ausencia de antecedentes quirúrgicos que pudieran ser la causa.

Abstract BACKGROUND: Vaginal evisceration is a rare entity, with less than 100 reports in the -literature, which is associated with multiple factors, the most important being the history of a gynecological surgical approach by vaginal approach. The clinical presentation is variable, and the treatment is based on emergency surgery to reduce the associated morbidity and mortality. CLINICAL CASE: The case of a 63-year-old female with no surgical history or vaginal procedures with a diagnosis of vaginal evisceration after performing a Valsalva maneuver when evacuating with a foreign body sensation in the vaginal canal, presenting a vaginal dome rupture, with evisceration and necrosis of the case is presented. 100 cm of terminal ileum who undergoes surgical time with resection, anastomosis as well as primary closure of vaginal defect, presents pathology report, cervical biopsy, as well as negative colposcopy of malignancy. CONCLUSION: So far, there are fewer than 100 reports of this complication, which requires suspicion and timely treatment to reduce the associated morbidity and mortality. What is relevant in this case is the absence of a surgical history that could be the cause.

A rare form of domestic accident: blast abdominal injury with evisceration of abdominal viscus

Evisceration of abdominal viscus following 'Flowerpot firecracker' (tubri) blast injury to the abdomen is a rare but dangerous form of domestic accident. Lack of knowledge and non-compliance of safety measures is the major reason for firecracker eventualities. A 10-year male child presented three hours post-injury with a wound over the upper abdomen. On examination there was evisceration of part of stomach along with colon through supraumbilical abdominal wound. Resuscitation and repair following exploratory laparotomy performed. Patient recovered well postoperatively. Public awareness and safety measures need to be taken to prevent the fatal outcomes of firecracker misuse.

A three-dimensional printed photopolymer resin implant for orbital rehabilitation for evisceration / Implante de resina fotocurável para evisceração produzido por impressora tridimensional

ABSTRACT Purpose: To evaluate the biocompatibility of three-dimensional (3D) printed orbital spheres for evisceration. Materials: A total of 10 consecutive patients (eight females and two males; mean age, 46.8 ± 14.2 years) underwent evisceration of blind painful eyes. 3D spherical implants produced by a rapid prototype machine were used to restore orbital volume. The implants were produced from a commercially available photocurable resin (Fullcure®). Systemic toxicity was evaluated by comparing serum biochemical measurements (creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, urea, alkaline phosphatase, and C-reactive protein) before and at 12 months after surgery. Local toxicity was assessed by the evaluation of signs of socket inflammation at the first postoperative month. Changes in implant size were determined by computed tomography scans at 2 and 12 months after surgery. Results: The postoperative evaluations were uneventful. The biochemical evaluation showed no significant changes after surgery. None of the patients presented signs of orbital implant inflammation, infection, exposure, or extrusion. Computed tomography scan evaluations revealed no changes in implant size. Conclusion: To the best of our knowledge, this is the first phase-1 clinical study to certify the biocompatibility of the Fullcure resin for orbital implants in humans. The 3D printing technology permits fast and accurate production of implants for this purpose.

RESUMO Objetivos: Avaliar a biocompatibilidade das esferas produzidas por impressora tridimensional em evisceração. Pacientes e métodos: Evisceração por olho cego doloroso foi realizada em 10 pacientes consecutivos (8 mulheres, idade média: 46.8 ± 14.2 anos). Os implantes esféricos foram produzidos pelo sistema de prototipagem rápida utilizando dados tridimensionais computadorizados. O material utilizado para produção dos implantes foi a resina fotocurável Fullcure®. A avaliação da toxicidade sistêmica do material foi realizada por meio da dosagem de marcadores bioquímicos (creatina fosfoquinase, aspartato aminotransferase, alanina aminotransferase, albumina, creatinina, ureia, fosfatase alcalina, e proteína C-reactiva) antes da cirurgia e aos 12 meses de pós-operatorio. A avaliação da toxicidade local foi realizada por meio do registro qualitativo dos sinais inflamatórios no lado operado durante o primeiro mês de pós-operatório. O tamanho dos implantes foi medido em tomografias computadorizadas (CT) aos 2 e 12 meses de pós-operatório. Resultados: A avaliação bioquímica mostrou que os marcadores estudados não sofreram alterações significativas após a cirurgia. Nenhum paciente apresentou sinais de inflamação atípica, infecção, exposição ou extrusão. A avaliação tomográfica não demonstrou mudanças nos tamanhos dos implantes. Conclusão: O presente trabalho é o primeiro estudo clínico realizado para atestar a biocompatibilidade dos implantes orbitais de resina fotocurável Fullcure. A produção dos implantes pela técnica de impressão tridimensional, utilizando essa resina, permite a disponibilização rápida e acurada do produto final

Risk factors for orbital implant exposure after evisceration: A case control study of 93 patients

Purpose: The study aims to analyze risk factors for exposure of orbital implants after evisceration by comparison of patients with and without exposure of implants. Methods: This is a case control study in retrospective interventional case series; Group A- implant exposures after evisceration, Group B - Patients on follow up after evisceration with implant, without exposure, with matched duration of follow up. The sample size is calculated for a power of 80. Results: Group A comprised 32 sockets with implant exposure, presenting at median 18 months after surgery; Group B included 61 eviscerated sockets, without implant exposure, with follow up median 36 months. Odds Ratio (OR) was calculated; infected eyes -OR 1.3, P = 0.6; phthisical eye - OR 1.4, P = 0.43; multiple prior surgeries- OR 1.55, P = 0.33. Group A had 59.3% porous implants, Group B 55.7%, - OR 1.3, P = 0.5. Mean implant size in Group A 19.06 mm, Group B 18.78 mm- showed no statistical difference. Multiple logistic regression analysis showed no significant risk factor for exposure. Surgeon factor was not analyzed since there were multiple surgeons. Conclusion: This is the first study with calculated sample size, comparing implant exposure patients to a control group. Porous implant material, presence of infection, phthisical scleral shell, and prior surgery showed higher trend of exposure (Odds ratio >1), but none was conclusive. Larger size of implant was not a risk factor for exposure. Eliminating the role of several factors in implant exposure allows the surgeon to make better surgical choices: such as place an implant of appropriate size, of a material of surgeon's choice, and do primary placement of implant in a patient with evisceration post-corneal ulcer or endophthalmitis. A hypothesis and a recommendation is that meticulous attention be paid to surgical technique.

Evisceración abdominal postraumática en un niño / Post-traumatic abdominal evisceration in a child

Introducción: Se considera un paciente politraumatizado aquel que presenta dos o más lesiones, de las que al menos una puede comprometer su vida o vaya a originar secuelas invalidantes. Una conducta inicial adecuada puede reducir la mortalidad de pacientes como el que se presenta, pues la atención inicial debe ser ordenada y sistemática; siempre se deben identificar y tratar con prioridad, las lesiones que comprometen la vida del paciente. Objetivo: Presentar un caso, que por su interés y singularidad en el mecanismo de acción, expone la secuencia de actuación que se llevó a cabo por cirujanos generales, fuera de un servicio de cirugía pediátrica. Caso clínico: Se reporta el caso de un paciente masculino de 6 años de edad, que acude al cuerpo de guardia politraumatizado y presenta una avulsión músculo cutánea abdominal con evisceración intestinal, al sufrir caída en movimiento con traumatismo abdominal penetrante con biela de pedal de una bicicleta. A pesar de no contar en la institución de atención, con servicio de cirugía pediátrica, se impuso la cirugía de emergencia por las condiciones del paciente. Conclusiones: Luego de laparotomía inicial con reconstrucción de la pared abdominal y cierre primario con puntos de seguridad, el paciente evolucionó de forma estable. Fue remitido para un servicio de terapia intensiva pediátrica, donde y evolucionó sin complicaciones, hasta su egreso(AU)

Introduction: A polytraumatized patient is considered to be one who presents two or more injuries, of which at least one may compromise his life or cause disabling sequelae. An adequate initial behavior can reduce the mortality of patients such as the one that occurs, because the initial attention must be orderly and systematic, the lesions that compromise the patient's life must always be identified and treated with priority. Objective: To present a case, which due to its interest and uniqueness in the mechanism of action, exposes the sequence of action that was carried out by general surgeons, outside of a pediatric surgery service. Clinical case: We report the case of a 6-year-old male patient who came to emergency, polytraumatized and presenting an abdominal skin muscle avulsion with intestinal evisceration, he suffered a fall during movement with penetrating abdominal trauma with a bike pedal crank. Despite not having a pediatric surgery service in the attending institution, emergency surgery was imposed due to the patient's conditions. Conclusions: After the initial laparotomy with reconstruction of the abdominal wall and primary closure with security points, the patients evolves in a stable way, he was referred to a pediatric intensive care service, where he evolved without complications until discharge(AU)

A rare complication of spontaneous rupture of incisional hernia: case report

Incisional hernia Complicates only 2%-10%. Spontaneous evisceration of content is very rare but whenever it occurs, it demands emergency surgery, to prevent further obstruction, strangulation of bowel and to cover its contents. The hernial contents can be covered primarily by mesh repair if the general condition of the patient and local condition of the operative site allows or can be covered by skin followed by delayed mesh repair. Authors report such rare case of spontaneous evisceration of omentum in 35 years old female patient who was known case of incisional hernia for 2 years. Neglect for early operative intervention or delay in seeking the treatment for an incisional hernia increases the risk of rupture.

Limited retromuscular fibrofatty tissue resection in upper blepharoplasty for senile patients

BACKGROUND: Studies of eyelid anatomy suggest an absence of supratarsal folds and a redundancy of retromuscular tissue in many Asians. Aggressive retromuscular tissue resection during senile blepharoplasty can lead to complications such as hematoma and extra fold formation. A thin fold is considered aesthetically pleasing, but upper eyelid hollowness is undesirable. Therefore, senile blepharoplasty allows relatively little room for retromuscular resection. METHODS: Between January 2016 and March 2019, blepharoplasty without a brow procedure was performed in 48 patients aged 55 years and older. In some patients with thin eyelids, the upper retromuscular tissue was explored, and the surgeon decided intraoperatively whether to perform resection. In total, 36 of 48 patients underwent retromuscular tissue resection, which was confined to the central and lateral aspects of the eyelid within 7–10 mm from the incision in the superior direction to create a crisp, thin fold without hollowness. The skin was closed, with the closure including the levator palpebrae superioris (levator) muscle, to create a weak, natural-looking, and dynamic fold instead of the buried dermo-levator suture typically created during double eyelid surgery. RESULTS: In the 72 eyelids that underwent resection, hematoma or extra fold formation was absent. In all cases, thin folds were achieved without an increase in the hollowness of the upper eyelid. Most patients were satisfied with their natural-looking postoperative appearance. CONCLUSIONS: When indicated, limited retromuscular resection is recommended in cases of senile blepharoplasty. The resection should be confined to the central and the lateral aspects of the eyelid, within 7–10 mm in the superior direction from the incision, to create a crisp thin fold without hollowness.

Peripapillary choroidal thickness in contralateral eyes after evisceration of diseased eyes / Espessura coroide peripapilar de olhos contralaterais após evisceração do olho doente

ABSTRACT Purpose: To evaluate peripapillary choroidal thickness changes in contralateral eyes of patients who had undergone evisceration of their diseased eyes. Methods: In this retrospective study, peripapillary choroidal thickness parameters in 34 eyes of 34 patients who had undergone diseased-eye evisceration between March 2014 and May 2016 were evaluated using spectral domain optical coherence tomography. The scans were manually delineated to identify the principal surfaces of Bruch's membrane, the Bruch's membrane opening, and the anterior sclera. Peripapillary choroidal thickness was measured between the Bruch's membrane and the anterior sclera at increasing distance away from the Bruch's membrane opening. The mean peripapillary choroidal thickness values in the contralateral eyes of the patients and those of the control group were compared. Results: The mean peripapillary choroidal thickness was higher in the contralateral eyes of the patients compared with that of normal eyes at all distances from the Bruch's membrane opening. Conclusion: Increased peripapillary choroidal thickness was noted in the contralateral eyes of the patients, potentially resulting in a thicker choroid. Although further investigation is required to determine the cause, these findings indicate the presence of a compensatory factor in the contralateral eyes.

RESUMO Objetivo: Avaliar as alterações da espessura coroide peripapilar em olhos contralaterais de pacientes submetidos à evisceração do olho doente. Métodos: Neste estudo retrospectivo, parâmetros da espessura coróide peripapilar de 34 olhos de 34 pacientes submetidos à evisceração, entre março de 2014 e maio de 2016, foram avaliados com tomografia de coerência óptica de domínio espectral. As varreduras foram manualmente delineadas para identificar as principais superfícies da membrana de Bruch, a abertura da membrana de Bruch e a esclera anterior. A espessura coroide peripapilar foi medida entre a membrana de Bruch e a esclera anterior a uma distância crescente da abertura da membrana de Bruch. Compararam-se os valores médios da espessura coroide peripapilar dos olhos contralaterais dos pacientes e do grupo controle. Resultados: A espessura coroide peripapilar média foi mais espessa nos olhos contralaterais dos pacientes, quando comparada com os olhos normais, em todas as distâncias da abertura da membrana de Bruch. Conclusão: O aumento da espessura coroide peripapilar foi notado nos olhos contralaterais dos pacientes. O espessamento da coroide pode ser resultante do distúrbio. Embora seja necessária uma investigação mais aprofundada para determinar a causalidade, esses achados podem apontar para um fator compensatório dos olhos contralaterais.

Indications for eye removal over a 13-year period at an ophthalmology referral center in São Paulo, Brazil / Indicações para remoção ocular ao longo de um período de 13 anos no centro de referência oftalmológica em São Paulo, Brazil

ABSTRACT Purpose: To analyze the indications and types of eye removal at Latin America's highest-volume ophthalmic reference center in São Paulo, Brazil. Methods: A retrospective analysis was conducted of surgical pathological reports in the electronic database of the Ophthalmology Department of the Universidade Federal de São Paulo Hospital of patients who underwent eye-removal procedures between January 2000 and December 2012. Results: A total of 412 cases met the inclusion criteria for this study. The most common indications for eye removal were ocular melanoma and retinoblastoma, representing 35.4% and 31.1% of the total cases, respectively. Other frequent indications included endophthalmitis (6.3%), nonspecific inflammation (4.1%), squamous cell carcinoma (3.6%), panophthalmitis (3.4%), and phthisis bulbi (1.2%). The remaining indications accounted for 14.8% of all cases, with each accounting for <1% of the total cases. Enucleation was the most common eye-removal procedure seen in our study. Conclusions: The two most common indications for eye removal were ocular melanoma and retinoblastoma. Alternative treatment options are effective in limiting the need for eye removal but are constrained by our public center's so cioeconomic context.

RESUMO Objetivo: Analisar os tipos e indicações para a remoção dos olhos no maior centro de referência oftalmológica da América Latina em São Paulo, Brasil. Métodos: Revisão retrospectiva de laudos cirúrgico patológico em uma base de dados eletrônica do Departamento de Oftalmologia do Hospital da Universidade Federal de São Paulo. Foram analisados pacientes submetidos ao procedimento de remoção oftálmica no período de janeiro de 2000 a dezembro de 2012. Resultados: Um total de 412 casos estiveram de acordo com os critérios de inclusão desse estudo. A indicação mais comum para remoção oftálmica foi Melanoma ocular e Retinoblastoma, representando, respectivamente, 35,4% e 31,1% do total de casos. Outras indicações frequentes incluíam Endoftalmite 6,3%, Inflamação inespecífica 4,1%, Carcinoma escamocelular 3,6%, Panoftalmite 3,4% e Phthisis Bulbi 1,2%. O restante das indicações totalizaram 14,8% de todos os casos, sendo que cada um correspondem com menos de 1% do total. Enucleação foi o procedimento de remoção oftálmica mais comum observado em nosso estudo. Conclusão: As duas indicações mais frequentes para remoção oftálmica no centro oftalmológico de referência do Brasil foi melanoma e retinoblastoma. Opções terapêuticas alternativas são efetivas para limitar a necessidade da remoção ocular, porém são restritos devido ao contexto socioeconômico de nossa população.

The reasons for evisceration after penetrating keratoplasty between 1995 and 2015 / As causas de evisceração após ceratoplastia penetrante entre 1995 e 2015

ABSTRACT Purpose: The purpose of this study was to determine the indications and frequency of evisceration after penetrating keratoplasty (PK). Methods: The medical records of all patients who underwent evisceration after PK between January 1, 1995 and December 31, 2015 at Ankara Training and Research Hospital were reviewed. Patient demographics and the surgical indications for PK, diagnosis for evisceration, frequency of evisceration, and the length of time between PK and evisceration were recorded. Results: The frequency of evisceration was 0.95% (16 of 1684), and the mean age of the patients who underwent evisceration was 56.31 ± 14.82 years. The most common indication for PK that resulted in evisceration was keratoconus (37.5%), and the most common underlying cause leading to evisceration was endophthalmitis (56.25%). The interval between PK and evisceration ranged from 9 to 78 months. Conclusions: Although keratoplasty is one of the most successful types of surgery among tissue transplantations, our findings show that it is associated with a possible risk of evisceration.

RESUMO Objetivo: O objetivo deste estudo foi determinar as indicações e a frequência de evisceração ocular após cirurgia de ceratoplastia penetrante ou transplante de córnea (PK). Métodos: Foram analisados os registros médicos de todos os pacientes submetidos à evisceração após PK entre 1º de janeiro de 1995 e 31 de dezembro de 2015 no Hospital de Treinamento e Pesquisa de Ankara. Foram registradas a demografia do paciente e as indicações cirúrgicas de PK, diagnóstico de evisceração, frequência de evisceração, tempo entre PK e evisceração. Resultados: A frequência de evisceração foi de 0,95% (16 de 1684) e a média de idade foi de 56,31 ± 14,82 anos. A indicação mais comum para PK que terminou na evis ceração foi o ceratocone (37,5%) e a causa subjacente à evisceração foi a endoftalmite (56,25%). O intervalo entre PK e evisceração variou de 9 a 78 meses. Conclusão: Embora a ceratoplastia seja uma das cirurgias mais bem sucedidas entre os transplantes de tecidos, pode-se deduzir do estudo que não é tão inócua, pois pode evoluir para a evisceração ocular.